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NMDAζ1 (phospho Ser890) rabbit pAb
AO-06-ES5648-100
Antibody Product Overview
| ELK.No | ES5648 |
| Product name | NMDAζ1 (phospho Ser890) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | IHC;IF;ELISA |
| Other name | GRIN1; NMDAR1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2902 |
| Human Swiss-Prot | Q05586 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NMDAR1 |
| Fields | >>Ras signaling pathway;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Circadian entrainment;>>Long-term potentiation;>>Glutamatergic synapse;>>Alzheimer disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Cocaine addiction;>>Amphetamine addiction;>>Nicotine addiction;>>Alcoholism |
| Gene name | GRIN1 |
| Protein name | Glutamate [NMDA] receptor subunit zeta-1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14810 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P35438 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 24408 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P35439 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NMDAR1 around the phosphorylation site of Ser890. AA range:856-905 |
| Specificity | Phospho-NMDAζ1 (S890) Polyclonal Antibody detects endogenous levels of NMDAζ1 protein only when phosphorylated at S890. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 105kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008], |
| Function | function:NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.,online information:NMDA receptor entry,PTM:NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subcellular location:Enriched in post-synaptic plasma membrane and post-synaptic densities.,subunit:Fo |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane . Cell junction, synapse, postsynaptic density . Enriched in postsynaptic plasma membrane and postsynaptic densities. . |
| Expression | Brain,Cerebellum,Hippocampus, |
Additional Images
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Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
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Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using NMDAR1 (Phospho-Ser890) Antibody
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Immunofluorescence analysis of A549 cells, using NMDAR1 (Phospho-Ser890) Antibody. The picture on the right is blocked with the phospho peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain, using NMDAR1 (Phospho-Ser890) Antibody. The picture on the right is blocked with the phospho peptide.
: AO-06-ES5648-100
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