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Antibody Product Overview
| ELK.No | ES5709 |
| Product name | Granzyme A rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | IHC;IF;ELISA |
| Other name | GZMA; CTLA3; HFSP; Granzyme A; CTL tryptase; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; Granzyme-1; Hanukkah factor; H factor; HF |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 3001 |
| Human Swiss-Prot | P12544 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Granzyme A |
| Fields | >>Neuroactive ligand-receptor interaction |
| Gene name | GZMA |
| Protein name | Granzyme A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P11032 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GRAA. AA range:61-110 |
| Specificity | Granzyme A Polyclonal Antibody detects endogenous levels of Granzyme A protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 29kD |
| Observed band (KD) | |
| Background | Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|-Xaa- in small molecule substrates.,function:This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys or Arg. May be involved in apoptosis.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subunit:Homodimer; disulfide-linked., |
| Subcellular location | [Isoform alpha]: Secreted . Cytoplasmic granule . Delivered into the target cell by perforin. . |
| Expression | Blood,Liver,T-cell, |
Additional Images
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Immunofluorescence analysis of HepG2 cells, using GRAA Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human heart tissue, using GRAA Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HUVECcells using MUTYH antibody.
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: AO-06-ES5709-50
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