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Antibody Product Overview
| ELK.No | ES5808 |
| Product name | ICAM-2 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | ICAM2; Intercellular adhesion molecule 2; ICAM-2; CD antigen CD102 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 3384 |
| Human Swiss-Prot | P13598 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ICAM-2 |
| Fields | >>Cell adhesion molecules;>>Natural killer cell mediated cytotoxicity |
| Gene name | ICAM2 |
| Protein name | Intercellular adhesion molecule 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P35330 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ICAM2. AA range:151-200 |
| Specificity | ICAM-2 Polyclonal Antibody detects endogenous levels of ICAM-2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 30kD |
| Background | The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008], |
| Function | function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.,online information:ICAM-2,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains., |
| Subcellular location | Membrane ; Single-pass type I membrane protein . Cell projection, microvillus . Co-localizes with RDX, EZR and MSN in microvilli. . |
| Expression | Aorta endothelial cell,Blood,Brain,Endothelial cell,Plasma,Spleen, |
Additional Images
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Western Blot analysis of 3T3 cells using ICAM-2 Polyclonal Antibody
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Western blot analysis of the lysates from HT-29 cells using ICAM2 antibody.
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: AO-06-ES5808-50
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