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Antibody Product Overview
| ELK.No | ES5855 |
| Product name | ALS rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | IGFALS; ALS; Insulin-like growth factor-binding protein complex acid labile subunit; ALS |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 3483 |
| Human Swiss-Prot | P35858 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ALS |
| Fields | >>Growth hormone synthesis, secretion and action |
| Gene name | IGFALS |
| Protein name | Insulin-like growth factor-binding protein complex acid labile subunit |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P70389 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IGFALS. AA range:303-352 |
| Specificity | ALS Polyclonal Antibody detects endogenous levels of ALS protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 66kD |
| Background | The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009], |
| Function | function:Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.,similarity:Contains 20 LRR (leucine-rich) repeats.,subunit:Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3.,tissue specificity:Plasma., |
| Subcellular location | Secreted, extracellular space. |
| Expression | Plasma. |
Additional Images
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Western Blot analysis of CoLo cells using ALS Polyclonal Antibody
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Western blot analysis of IGFALS Antibody. The lane on the right is blocked with the IGFALS peptide.
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Western blot analysis of the lysates from RAW264.7cells using IGFALS antibody.
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: AO-06-ES5855-50
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