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Antibody Product Overview
| ELK.No | ES6151 |
| Product name | MARCKS rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IF;ELISA |
| Other name | MARCKS; MACS; PRKCSL; Myristoylated alanine-rich C-kinase substrate; MARCKS; Protein kinase C substrate; 80 kDa protein, light chain; 80K-L protein; PKCSL |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 4082 |
| Human Swiss-Prot | P29966 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MARCKS |
| Fields | >>Fc gamma R-mediated phagocytosis;>>MicroRNAs in cancer |
| Gene name | MARCKS |
| Protein name | Myristoylated alanine-rich C-kinase substrate |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 17118 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P26645 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P30009 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MARCKS. AA range:126-175 |
| Specificity | MARCKS Polyclonal Antibody detects endogenous levels of MARCKS protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 31kD |
| Background | The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008], |
| Function | function:MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.,PTM:Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.,similarity:Belongs to the MARCKS family., |
| Subcellular location | Cytoplasm, cytoskeleton . Membrane ; Lipid-anchor . |
| Expression | Blood,Brain,Epithelium,Muscle,Skin, |
Additional Images
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Immunofluorescence analysis of A549 cells, using MARCKS Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from Jurkat cells, using MARCKS Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES6151-100
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