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Antibody Product Overview
| ELK.No | ES6165 |
| Product name | MAGE-A5 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | MAGEA5; MAGE5; Melanoma-associated antigen 5; Cancer/testis antigen 1.5; CT1.5; MAGE-5 antigen |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 4104 |
| Human Swiss-Prot | P43359 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MAGE-A5 |
| Fields | |
| Gene name | MAGEA5 |
| Protein name | Melanoma-associated antigen 5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MAGEA5. AA range:68-117 |
| Specificity | MAGE-A5 Polyclonal Antibody detects endogenous levels of MAGE-A5 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 36kD |
| Background | This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This MAGEA gene encodes a protein that is C-terminally truncated compared to other family members, and this gene can be alternatively interpreted to be a pseudogene. The protein is represented in this Gene record in accordance with the assumed protein-coding status defined in the literature. Read-through transcription exists between this gene and the upstream melanoma antigen family A, 10 (MAGEA10) gene. [pr |
| Function | function:Not known, though may play a role tumor transformation or progression.,similarity:Contains 1 MAGE domain.,tissue specificity:Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes., |
| Subcellular location | |
| Expression | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. |
Additional Images
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Western Blot analysis of 3T3 cells using MAGE-A5 Polyclonal Antibody
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Western blot analysis of lysates from NIH/3T3 cells, using MAGEA5 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from K562 cells using MAGEA5 antibody.
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: AO-06-ES6165-50
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