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Antibody Product Overview
| ELK.No | ES6706 |
| Product name | TMEM16A rabbit pAb |
| Reactivity | Human;Mouse; |
| Applications | IF;ELISA |
| Other name | ANO1; DOG1; ORAOV2; TAOS2; TMEM16A; Anoctamin-1; Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 55107 |
| Human Swiss-Prot | Q5XXA6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TMEM16A |
| Fields | |
| Gene name | ANO1 |
| Protein name | Anoctamin-1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8BHY3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TM16A. AA range:921-970 |
| Specificity | TMEM16A Polyclonal Antibody detects endogenous levels of TMEM16A protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 114kD |
| Observed band (KD) | |
| Background | domain:The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.,function:Acts as a calcium-activated chloride channel. Required for normal tracheal development.,similarity:Belongs to the anoctamin family.,tissue specificity:Broadly expressed with higher levels in liver and skeletal muscle., |
| Function | domain:The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.,function:Acts as a calcium-activated chloride channel. Required for normal tracheal development.,similarity:Belongs to the anoctamin family.,tissue specificity:Broadly expressed with higher levels in liver and skeletal muscle., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Cytoplasm . Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors. . |
| Expression | Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles. |
Additional Images
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Immunofluorescence analysis of HeLa cells, using TM16A Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES6706-100
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