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Antibody Product Overview
| ELK.No | ES6721 |
| Product name | CD158f2 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IF;ELISA |
| Other name | KIR2DL5B; CD158F; CD158F2; KIR2DL5; KIR2DLX; Killer cell immunoglobulin-like receptor 2DL5B; CD158 antigen-like family member F2; Killer cell immunoglobulin-like receptor 2DLX; CD antigen CD158f2 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 553128 |
| Human Swiss-Prot | Q8NHK3 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CD158f2 |
| Fields | |
| Gene name | KIR2DL5B |
| Protein name | Killer cell immunoglobulin-like receptor 2DL5B |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human KIR2DL5B. AA range:161-210 |
| Specificity | CD158f2 Polyclonal Antibody detects endogenous levels of CD158f2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 40kD |
| Background | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B(KIR2DL5B) Homo sapiens Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the |
| Function | function:Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains., |
| Subcellular location | Cell membrane; Single-pass type I membrane protein. |
| Expression |
Additional Images
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Immunofluorescence analysis of A549 cells, using KIR2DL5B Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES6721-50
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