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Antibody Product Overview
| ELK.No | ES6897 |
| Product name | PTH/PTHrP-R rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | PTH1R; PTHR; PTHR1; Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 5745 |
| Human Swiss-Prot | Q03431 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PTH/PTHrP-R |
| Fields | >>Neuroactive ligand-receptor interaction;>>Parathyroid hormone synthesis, secretion and action;>>Endocrine and other factor-regulated calcium reabsorption |
| Gene name | PTH1R |
| Protein name | Parathyroid hormone/parathyroid hormone-related peptide receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 19228 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P41593 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 56813 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P25961 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PTHR1. AA range:145-194 |
| Specificity | PTH/PTHrP-R Polyclonal Antibody detects endogenous levels of PTH/PTHrP-R protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 52kD |
| Background | The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010], |
| Function | disease:Defects in PTH1R are a cause of primary failure of tooth eruption (PFE) [MIM:125350]. PFE is a rare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption.,disease:Defects in PTH1R are the cause of chondrodysplasia Blomstrand type (BOCD) [MIM:215045]. BOCD is a severe skeletal dysplasia.,disease:Defects in PTH1R are the cause of Eiken syndrome [MIM:600002]; also called Eiken skeletal dysplasia or bone modeling defect of hands and feet. Eiken syndrome is a rare familial autosomal recessive skeletal dysplasia. It is characterized by multiple epiphyseal dysplasia, with extremely retarded ossification, pri |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . |
| Expression | Expressed in most tissues. Most abundant in kidney, bone and liver. |
Additional Images
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Western Blot analysis of COLO cells using PTH/PTHrP-R Polyclonal Antibody diluted at 1:1000
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Immunofluorescence analysis of MCF7 cells, using PTHR1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PTHR1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from Jurkat cells, using PTHR1 Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES6897-50
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