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Antibody Product Overview
| ELK.No | ES6915 |
| Product name | NEDL2 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | HECW2; KIAA1301; NEDL2; E3 ubiquitin-protein ligase HECW2; HECT; C2 and WW domain-containing protein 2; NEDD4-like E3 ubiquitin-protein ligase 2 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 57520 |
| Human Swiss-Prot | Q9P2P5 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NEDL2 |
| Fields | |
| Gene name | HECW2 |
| Protein name | E3 ubiquitin-protein ligase HECW2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q6I6G8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HECW2. AA range:481-530 |
| Specificity | NEDL2 Polyclonal Antibody detects endogenous levels of NEDL2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 140-150kD |
| Background | function:E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with TP73.,tissue specificity:Predominantly expressed in adult brain, lung and heart., |
| Function | function:E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with TP73.,tissue specificity:Predominantly expressed in adult brain, lung and heart., |
| Subcellular location | Cytoplasm . Cytoplasm, cytoskeleton, spindle . |
| Expression | Predominantly expressed in adult brain, lung and heart. |
Additional Images
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Western Blot analysis of 3T3 cells using NEDL2 Polyclonal Antibody diluted at 1:1000
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Western blot analysis of lysates from LOVO and HepG2 cells, using HECW2 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES6915-100
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