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Antibody Product Overview
| ELK.No | ES7053 |
| Product name | Bcl-7a rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | BCL7A; B-cell CLL/lymphoma 7 protein family member A |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 605 |
| Human Swiss-Prot | Q4VC05 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Bcl-7a |
| Fields | |
| Gene name | BCL7A |
| Protein name | B-cell CLL/lymphoma 7 protein family member A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 77045 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9CXE2 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BCL7A. AA range:21-70 |
| Specificity | Bcl-7a Polyclonal Antibody detects endogenous levels of Bcl-7a protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 22kD |
| Background | This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Function | disease:Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the BCL7 family., |
| Subcellular location | |
| Expression | Brain,Thalamus, |
Additional Images
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Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES7053-100
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