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Antibody Product Overview
| ELK.No | ES7166 |
| Product name | Eos rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | IKZF4; KIAA1782; ZNFN1A4; Zinc finger protein Eos; Ikaros family zinc finger protein 4 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 64375 |
| Human Swiss-Prot | Q9H2S9 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Eos |
| Fields | |
| Gene name | IKZF4 |
| Protein name | Zinc finger protein Eos |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 22781 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8C208 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IKZF4. AA range:471-520 |
| Specificity | Eos Polyclonal Antibody detects endogenous levels of Eos protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 64kD |
| Background | Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002], |
| Function | domain:C-terminal zinc fingers mediate homodimerization.,domain:The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.,function:DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems.,miscellaneous:'Eos' is a Greek word for rising sun.,similarity:Belongs to the Ikaros C2H2-type zinc-finger protein family.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Self-associates and interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF5. Interacts with CTBP2, SPI1 and MITF.,tissue specificity:Highly expressed in skeletal muscle, low levels of expressi |
| Subcellular location | Nucleus . |
| Expression | Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively. |
Additional Images
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Western blot analysis of the lysates from HeLa cells using IKZF4 antibody.
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: AO-06-ES7166-100
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