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Antibody Product Overview
| ELK.No | ES7199 |
| Product name | CD75 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | ST6GAL1; SIAT1; Beta-galactoside alpha-2; 6-sialyltransferase 1; Alpha 2,6-ST 1; B-cell antigen CD75; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI; Sialyltransferase 1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6480 |
| Human Swiss-Prot | P15907 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ST6GAL1 |
| Fields | >>N-Glycan biosynthesis;>>Other types of O-glycan biosynthesis;>>Metabolic pathways |
| Gene name | ST6GAL1 |
| Protein name | Beta-galactoside alpha-2,6-sialyltransferase 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20440 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q64685 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25197 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P13721 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ST6GAL1. AA range:171-220 |
| Specificity | CD75 Polyclonal Antibody detects endogenous levels of CD75 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 42kD |
| Background | This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009], |
| Function | catalytic activity:CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.,function:Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.,online information:GlycoGene database,online information:ST6Gal I,pathway:Protein modification; protein glycosylation.,PTM:The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme.,PTM:The soluble form derives from the membrane form by proteolytic processing.,similarity:Belongs to the glycosyltransferase 29 family.,subcellular location:Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid., |
| Subcellular location | Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Secreted. Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid. |
| Expression | Liver,Lymph,Placenta,Skin,Spleen,Thymus, |
Additional Images
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Western Blot analysis of COLO cells using CD75 Polyclonal Antibody diluted at 1:2000
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Immunohistochemical analysis of paraffin-embedded Human stomach. 1, Antibody was diluted at 1:200(4° overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
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Immunohistochemical analysis of paraffin-embedded Human stomach. 1, Antibody was diluted at 1:200(4° overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
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Immunohistochemical analysis of paraffin-embedded Human stomach. 1, Antibody was diluted at 1:200(4° overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
: AO-06-ES7199-50
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