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Antibody Product Overview
| ELK.No | ES7218 |
| Product name | GABA T-1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | SLC6A1; GABATR; GABT1; GAT1; Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6529 |
| Human Swiss-Prot | P30531 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GABA T-1 |
| Fields | >>Synaptic vesicle cycle;>>GABAergic synapse |
| Gene name | SLC6A1 |
| Protein name | Sodium- and chloride-dependent GABA transporter 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 232333 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P31648 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 79212 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P23978 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SLC6A1. AA range:381-430 |
| Specificity | GABA T-1 Polyclonal Antibody detects endogenous levels of GABA T-1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 67kD |
| Background | The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009], |
| Function | domain:The PDZ domain-binding motif is involved in the interaction with MPP5.,function:Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.,miscellaneous:This protein is the target of psychomotor stimulants such as amphetamines or cocaine.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,subcellular location:Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons.,subunit:Interacts with MPP5., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Cell junction, synapse, presynapse . Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity). . |
| Expression | Brain, |
Additional Images
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Western blot analysis of SLC6A1 Antibody. The lane on the right is blocked with the SLC6A1 peptide.
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Western blot analysis of the lysates from HeLa cells using SLC6A1 antibody.
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: AO-06-ES7218-50
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