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Antibody Product Overview
| ELK.No | ES7597 |
| Product name | Oncogene TIM rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | ARHGEF5; TIM; Rho guanine nucleotide exchange factor 5; Ephexin-3; Guanine nucleotide regulatory protein TIM; Oncogene TIM; Transforming immortalized mammary oncogene; p60 TIM |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 7984 |
| Human Swiss-Prot | Q12774 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Oncogene TIM |
| Fields | |
| Gene name | ARHGEF5 |
| Protein name | Rho guanine nucleotide exchange factor 5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ARHGEF5. AA range:191-240 |
| Specificity | Oncogene TIM Polyclonal Antibody detects endogenous levels of Oncogene TIM protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008], |
| Function | similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH3 domain.,tissue specificity:Mainly expressed in kidney, liver, pancreas, lung and placenta., |
| Subcellular location | Cytoplasm . Nucleus . Cell projection, podosome . |
| Expression | Ubiquitously expressed with highest levels in placenta. High levels are also found in colon, kidney, trachea, prostate, liver, pancreas, pituitary gland, thyroid gland and mammary gland. In fetal tissues, expressed at high levels in kidney, lung and liver (PubMed:15601624). Expressed at low levels in lung and heart (PubMed:14662653). |
Additional Images
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Western blot analysis of lysates from RAW264.7 cells, using ARHGEF5 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from K562 cells using ARHGEF5 antibody.
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: AO-06-ES7597-50
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