Français
English
Antibody Product Overview
| ELK.No | ES7716 |
| Product name | CdcA7 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | CDCA7; JPO1; Cell division cycle-associated protein 7; Protein JPO1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 83879 |
| Human Swiss-Prot | Q9BWT1 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CdcA7 |
| Fields | |
| Gene name | CDCA7 |
| Protein name | Cell division cycle-associated protein 7 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 66953 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9D0M2 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 311742 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q4KM91 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDCA7. AA range:141-190 |
| Specificity | CdcA7 Polyclonal Antibody detects endogenous levels of CdcA7 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 43kD |
| Background | cell division cycle associated 7(CDCA7) Homo sapiens This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008], |
| Function | function:Participates in MYC-mediated cell transformation; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.,induction:Activated by MYC and possibly E2F1.,miscellaneous:CDCA7 expression is correlated with MYC expression in lymphoblastoid, lymphoma and breast cancer cell lines.,tissue specificity:Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML) blast crisis., |
| Subcellular location | Nucleus. Cytoplasm. Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-163. |
| Expression | Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML) blast crisis. |
Additional Images
No image
Western blot analysis of lysates from K562 cells, using CDCA7 Antibody. The lane on the right is blocked with the synthesized peptide.
No image
No image
No image
: AO-06-ES7716-50
: 10 Items
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package