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Antibody Product Overview
| ELK.No | ES7810 |
| Product name | CPZ rabbit pAb |
| Reactivity | Human;Rat |
| Applications | WB;ELISA |
| Other name | CPZ; Carboxypeptidase Z; CPZ |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8532 |
| Human Swiss-Prot | Q66K79 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CPZ |
| Fields | |
| Gene name | CPZ |
| Protein name | Carboxypeptidase Z |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8R4V4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 83575 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O54858 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from CPZ . at AA range: 330-410 |
| Specificity | CPZ Polyclonal Antibody detects endogenous levels of CPZ protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 73kD |
| Background | carboxypeptidase Z(CPZ) Homo sapiens This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], |
| Function | cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Inhibited by 2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (MGTA) and guanidinoethylmercaptosuccinic acid (GEMSA). Inhibited by chelating agents such as EDTA and EGTA.,function:Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.,similarity:Belongs to the peptidase M14 family.,similarity:Contains 1 FZ (frizzled) domain.,tissue specificity:In placenta, it is present within invasive trophoblasts and in the surrounding extracellular space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing adenomas) (at protein level). Widely express |
| Subcellular location | Secreted, extracellular space, extracellular matrix . |
| Expression | In placenta, it is present within invasive trophoblasts and in the surrounding extracellular space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing adenomas) (at protein level). Widely expressed. |
Additional Images
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Western Blot analysis of HEK293 lysis, using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000
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: AO-06-ES7810-50
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