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Antibody Product Overview
| ELK.No | ES7853 |
| Product name | VAMP-4 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | IF;ELISA |
| Other name | VAMP4; Vesicle-associated membrane protein 4; VAMP-4 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8674 |
| Human Swiss-Prot | O75379 |
| Source | Rabbit |
| Isotype | IgG |
| Target | VAMP4 |
| Fields | >>SNARE interactions in vesicular transport |
| Gene name | VAMP4 |
| Protein name | Vesicle-associated membrane protein 4 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | O70480 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human VAMP4. AA range:1-50 |
| Specificity | VAMP-4 Polyclonal Antibody detects endogenous levels of VAMP-4 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 16kD |
| Observed band (KD) | |
| Background | Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008], |
| Function | function:Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.,similarity:Belongs to the synaptobrevin family.,similarity:Contains 1 v-SNARE coiled-coil homology domain.,subcellular location:Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.,subunit:Identified in a complex containing STX6, STX13, VAMP4 and VTI1A., |
| Subcellular location | Golgi apparatus, trans-Golgi network membrane ; Single-pass type IV membrane protein . Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles. |
| Expression | B-cell,Bone marrow,Epithelium,Liver,Urinary bladder, |
Additional Images
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Immunofluorescence analysis of A549 cells, using VAMP4 Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES7853-50
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