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Antibody Product Overview
| ELK.No | ES8093 |
| Product name | GASP-1 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | IHC;IF;ELISA |
| Other name | GPRASP1; GASP; KIAA0443; G-protein coupled receptor-associated sorting protein 1; GASP-1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9737 |
| Human Swiss-Prot | Q5JY77 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GASP-1 |
| Fields | |
| Gene name | GPRASP1 |
| Protein name | G-protein coupled receptor-associated sorting protein 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q5U4C1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GASP1. AA range:741-790 |
| Specificity | GASP-1 Polyclonal Antibody detects endogenous levels of GASP-1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 157kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010], |
| Function | function:May modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes.,similarity:Belongs to the GPRASP family.,subunit:Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as D2 dopamine receptor/DRD2 (By similarity), delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4. Interacts with PER1.,tissue specificity:Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra., |
| Subcellular location | Cytoplasm . |
| Expression | Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra. |
Additional Images
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Immunofluorescence analysis of A549 cells, using GASP1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GASP1 Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES8093-50
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