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Antibody Product Overview
| ELK.No | ES8369 |
| Product name | CD269 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | TNFRSF17; BCM; BCMA; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 608 |
| Human Swiss-Prot | Q02223 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CD269 |
| Fields | >>Cytokine-cytokine receptor interaction;>>Intestinal immune network for IgA production |
| Gene name | TNFRSF17 |
| Protein name | Tumor necrosis factor receptor superfamily member 17 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | O88472 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from the Internal region of human CD269. |
| Specificity | CD269 Polyclonal Antibody detects endogenous levels of CD269 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 20kD |
| Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008], |
| Function | disease:A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.,function:Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.,similarity:Contains 1 TNFR-Cys repeat.,subcellular location:Perinuclear Golgi-like structures.,subunit:Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:Expressed in mature B-cells, but not in T-cells or monocytes., |
| Subcellular location | Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Perinuclear Golgi-like structures. |
| Expression | Expressed in mature B-cells, but not in T-cells or monocytes. |
Additional Images
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Western blot analysis of L929 293T MCF7 HELA using CD269 antibody. Antibody was diluted at 1:2000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Western blot analysis of K562/JK using CD269 antibody. Antibody was diluted at 1:2000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES8369-100
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