Français
English
Antibody Product Overview
| ELK.No | ES8525 |
| Product name | CLECSF6 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | C-type lectin domain family 4 member A (C-type lectin DDB27) (C-type lectin superfamily member 6) (Dendritic cell immunoreceptor) (Lectin-like immunoreceptor) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 50856 |
| Human Swiss-Prot | Q9UMR7 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CLECSF6 |
| Fields | |
| Gene name | CLEC4A |
| Protein name | CLECSF6 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 26888 |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9QZ15 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human CLEC4A. AA range:161-210 |
| Specificity | CLECSF6 Polyclonal Antibody detects endogenous levels of CLECSF6 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 28kD |
| Background | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008], |
| Function | domain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.,induction:Agonists of neutrophils GM-CSF, IL-3, IL-4 and IL-13 up-regulated mRNA expression of isoform 2.,online information:DCIR,similarity:Contains 1 C-type lectin domain.,subunit:May interact with PTPN6 via its ITIM motif.,tissue specificity:Expressed in dendritic cells, myeloid ce |
| Subcellular location | Cell membrane ; Single-pass type II membrane protein ; Extracellular side . |
| Expression | Expressed preferentially in hematopoietic tissues. Expressed in all circulating Ag-presenting cells such as dendritic cells, myeloid cells, monocytes, macrophages, B-cells and epidermal Langerhans cells (at protein level). Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. |
Additional Images
No image
Western Blot analysis of HEPG2 cells using CLECSF6 Polyclonal Antibody diluted at 1:500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
No image
Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200
No image
Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200
No image
Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
: AO-06-ES8525-100
: 10 Items
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package