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Antibody Product Overview
| ELK.No | ES8545 |
| Product name | MYOZ2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA;IHC |
| Other name | MYOZ2 C4orf5 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 51778 |
| Human Swiss-Prot | Q9NPC6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MYOZ2 |
| Fields | |
| Gene name | MYOZ2 C4orf5 |
| Protein name | myozenin 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 59006 |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9JJW5 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human MYOZ2. AA range:21-70 |
| Specificity | The antibody detects endogenous MYOZ2 protein |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 30kD |
| Background | The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder. [provided by RefSeq, Aug 2011], |
| Function | function:Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.,similarity:Belongs to the myozenin family.,subcellular location:Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle.,subunit:Interacts via its C-terminus with spectrin repeats 3 and 4 of ACTN2. Interacts with ATCN1, LDB3, MYOT and PPP3CA.,tissue specificity:Expressed specifically in heart and skeletal muscle., |
| Subcellular location | Cytoplasm, myofibril, sarcomere, Z line . Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle. . |
| Expression | Expressed specifically in heart and skeletal muscle. |
Additional Images
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Western Blot analysis of hepg2 cells using Antibody diluted at 500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human cervical carcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES8545-100
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