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Antibody Product Overview
| ELK.No | ES8589 |
| Product name | IL-31 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | Interleukin-31 (IL-31) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 386653 |
| Human Swiss-Prot | Q6EBC2 |
| Source | Rabbit |
| Isotype | IgG |
| Target | IL-31 |
| Fields | >>Cytokine-cytokine receptor interaction |
| Gene name | IL31 |
| Protein name | Interleukin-31 (IL-31) |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 76399 |
| Mouse gene link | |
| Mouse Swiss-Prot | Q6EAL8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human IL31. AA range:21-70 |
| Specificity | The antibody detects endogenous IL-31 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000, IHC-p 1:50-200 ELISA 1:10000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 65kD |
| Background | IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008], |
| Function | function:Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.,induction:Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD).,tissue specificity:Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea., |
| Subcellular location | Secreted . |
| Expression | Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea. |
Additional Images
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Western blot analysis of Hela Cell Lysate using antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-testis, antibody was diluted at 1:200
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Immunohistochemical analysis of paraffin-embedded human-testis, antibody was diluted at 1:200
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Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:200
: AO-06-ES8589-50
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