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Corticotropin-releasing factor receptor 2 rabbit pAb
AO-06-ES8600-50
Antibody Product Overview
| ELK.No | ES8600 |
| Product name | Corticotropin-releasing factor receptor 2 rabbit pAb |
| Reactivity | Human;Rat |
| Applications | WB;ELISA |
| Other name | Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1395 |
| Human Swiss-Prot | Q13324 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CRF-RII |
| Fields | >>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Cushing syndrome |
| Gene name | CRHR2 CRF2R CRH2R |
| Protein name | Corticotropin-releasing factor receptor 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q60748 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P47866 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthetic peptide from human protein at AA range: 221-295 |
| Specificity | The antibody detects endogenous Corticotropin-releasing factor receptor 2 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 48kD |
| Background | The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011], |
| Function | function:This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 2 family., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . |
| Expression | Amygdala,Brain,Skeletal muscle, |
Additional Images
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Western blot analysis of RAT-BRAIN Cell Lysate, antibody was diluted at 1:1000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES8600-50
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