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Histone H2B (Acetyl Lys24/25) rabbit pAb
AO-06-ES8626-50
Antibody Product Overview
| ELK.No | ES8626 |
| Product name | Histone H2B (Acetyl Lys24/25) rabbit pAb |
| Reactivity | Human;Rat;Mouse |
| Applications | WB;ELISA |
| Other name | H2BFS; Histone H2B type F-S; Histone H2B.s; H2B/s;H2BK2425AC |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 255626 |
| Human Swiss-Prot | Q96A08/P33778/P62807 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Histone H2B |
| Fields | >>Neutrophil extracellular trap formation;>>Alcoholism;>>Viral carcinogenesis;>>Systemic lupus erythematosus |
| Gene name | Histone H2B |
| Protein name | Histone H2B |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthetic Acetyl peptide from human protein at AA range: 24/25 |
| Specificity | The antibody detects endogenous Histone H2B when Acetyl occurs at Lys24 or 25) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 15kD |
| Background | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015], |
| Function | function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,PTM:Monoubiquitination of Lys-122 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II.,similarity:Belongs to the histone H2B family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one |
| Subcellular location | Nucleus . Chromosome . |
| Expression | Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells. |
Additional Images
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Western blot analysis of K562 mouse-lung lysate, antibody was diluted at 2000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES8626-50
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