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Antibody Product Overview
| ELK.No | ES8635 |
| Product name | Mox1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | NADPH oxidase 1 (NOX-1;EC 1.-.-.-;Mitogenic oxidase 1;MOX-1;NADH/NADPH mitogenic oxidase subunit P65-MOX;NOH-1) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 27035 |
| Human Swiss-Prot | Q9Y5S8 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Mox1 |
| Fields | >>Osteoclast differentiation;>>AGE-RAGE signaling pathway in diabetic complications;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Chemical carcinogenesis - reactive oxygen species;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis |
| Gene name | NOX1 MOX1 NOH1 |
| Protein name | NADPH oxidase 1 (NOX-1) (EC 1.-.-.-) (Mitogenic oxidase 1) (MOX-1) (NADH/NADPH mitogenic oxidase subunit P65-MOX) (NOH-1) |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 237038 |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8CIZ9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q9WV87 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthetic peptide from human protein at AA range: 210-260 |
| Specificity | The antibody detects endogenous Mox1 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 65kD |
| Background | This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012], |
| Function | cofactor:FAD .,cofactor:NADP .,enzyme regulation:The oxidase activity is potentiated by NOXA1 and NOXO1.,function:NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 ferric oxidoreductase domain.,subunit:NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interacts with NOXA1 and NOXO1.,tissue specificity:NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH-1S is dete |
| Subcellular location | Cell projection, invadopodium membrane ; Multi-pass membrane protein . Cell membrane . |
| Expression | NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH-1S is detected only in colon and colon carcinoma cells. |
Additional Images
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Western blot analysis of 293T Hela VEC KB mouse-kidney 3T3 lysate, antibody was diluted at 2000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
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Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
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Immunohistochemical analysis of paraffin-embedded human-stomach, antibody was diluted at 1:200
: AO-06-ES8635-100
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