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Antibody Product Overview
| ELK.No | ES8848 |
| Product name | V-ATPase S1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 537 |
| Human Swiss-Prot | Q15904 |
| Source | Rabbit |
| Isotype | IgG |
| Target | V-ATPase S1 |
| Fields | >>Oxidative phosphorylation;>>Metabolic pathways;>>Lysosome;>>Phagosome;>>Vibrio cholerae infection;>>Epithelial cell signaling in Helicobacter pylori infection;>>Tuberculosis;>>Hepatitis B;>>Human papillomavirus infection;>>Rheumatoid arthritis |
| Gene name | ATP6AP1 |
| Protein name | V-ATPase S1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 54411 |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9R1Q9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human V-ATPase S1. at AA range: 421-470 |
| Specificity | V-ATPase S1 Polyclonal Antibody detects endogenous levels of V-ATPase S1 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 51kD |
| Background | This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013], |
| Function | function:Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.,similarity:Belongs to the vacuolar ATPase subunit S1 family.,subunit:Composed of at least 10 subunits.,tissue specificity:Ubiquitous., |
| Subcellular location | Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Single-pass type I membrane protein . Not detected in trans-Golgi network. . |
| Expression | widely expressed, with highest levels in brain and lowest in liver and duodenum. |
Additional Images
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Western Blot analysis of 1,mouse-lung 2,mouse-brain 3,mouse-spleen 4,mouse-kidney cells using primary antibody diluted at 1:500(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour)
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: AO-06-ES8848-50
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