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Antibody Product Overview
| ELK.No | ES9528 |
| Product name | PDE2A rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 5138 |
| Human Swiss-Prot | O00408 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PDE2A |
| Fields | >>Purine metabolism;>>Metabolic pathways;>>cGMP-PKG signaling pathway;>>Olfactory transduction;>>Aldosterone synthesis and secretion;>>Morphine addiction |
| Gene name | PDE2A |
| Protein name | cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q922S4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q01062 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | PDE2A Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 103kD |
| Background | alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,function:Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP).,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,similarity:Contains 2 GAF domains.,subunit:Homodimer.,tissue specificity:Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas., |
| Function | alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,function:Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP).,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,similarity:Contains 2 GAF domains.,subunit:Homodimer.,tissue specificity:Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas., |
| Subcellular location | [Isoform PDE2A3]: Cell membrane ; Lipid-anchor .; [Isoform PDE2A2]: Mitochondrion matrix . Mitochondrion inner membrane . Mitochondrion outer membrane .; [Isoform PDE2A1]: Cytoplasm .; [Isoform 5]: Mitochondrion . |
| Expression | Widely expressed (PubMed:9210593, PubMed:29392776). Expressed in brain, with high expression observed in the corpus striatum (PubMed:29392776). Also expressed in heart, placenta, lung, skeletal muscle, kidney and pancreas (PubMed:9210593, PubMed:29392776). |
Additional Images
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Western Blot analysis of Hela lysis, using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000
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: AO-06-ES9528-50
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