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Antibody Product Overview
| ELK.No | ES9742 |
| Product name | TGIF2 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 60436 |
| Human Swiss-Prot | Q9GZN2 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TGIF2 |
| Fields | >>TGF-beta signaling pathway |
| Gene name | TGIF2 |
| Protein name | Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8C0Y1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TGIF2 Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 26kD |
| Background | The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010], |
| Function | function:Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.,miscellaneous:TGIF2 is amplified and overexpressed in several ovarian cancer cell lines.,PTM:The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.,similarity:Belongs to the TALE/TGIF homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subcellular location:Excluded from nucleoli.,subunit:Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1.,tissue specificity:Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate., |
| Subcellular location | Nucleus. Excluded from nucleoli. |
| Expression | Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate. |
Additional Images
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Western blot analysis of lysates from SH-SY5Y cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES9742-100
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