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Antibody Product Overview
| ELK.No | ES9849 |
| Product name | MYO1A rabbit pAb |
| Reactivity | Human;Rat;Mouse |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 4640 |
| Human Swiss-Prot | Q9UBC5 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MYO1A |
| Fields | >>Pathogenic Escherichia coli infection |
| Gene name | MYO1A MYHL |
| Protein name | Unconventional myosin-Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | O88329 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q62774 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 370-450 |
| Specificity | MYO1A Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 114kD |
| Background | This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional skeletal muscle myosin-1 (MYH1). Unconventional myosins contain the basic domains characteristic of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with autosomal dominant deafness. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Dec 2011], |
| Function | disease:Defects in MYO1A are the cause of non-syndromic sensorineural deafness autosomal dominant type 48 (DFNA48) [MIM:607841]. DFNA48 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,function:Involved in directing the movement of organelles along actin filaments .,similarity:Contains 1 myosin head-like domain.,similarity:Contains 3 IQ domains., |
| Subcellular location | cytoplasm,microvillus,brush border,basal plasma membrane,basolateral plasma membrane,apical plasma membrane,lateral plasma membrane,myosin complex,cortical actin cytoskeleton,filamentous actin,plasma membrane raft, |
| Expression | Intestine,Jejunum,Placenta, |
Additional Images
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Western Blot analysis of varius cell lysis. Primary Antibody was diluted at 1:1000. Secondary antibody(catalog#:RS23920 was diluted at 1:10000
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: AO-06-ES9849-50
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