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Antibody Product Overview
| ELK.No | ES9967 |
| Product name | P2RX1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 5023 |
| Human Swiss-Prot | P51575 |
| Source | Rabbit |
| Isotype | IgG |
| Target | P2RX1 |
| Fields | >>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Platelet activation |
| Gene name | P2RX1 P2X1 |
| Protein name | P2X purinoceptor 1 (P2X1) (ATP receptor) (Purinergic receptor) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P51576 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P47824 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 150-230 |
| Specificity | P2RX1 Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 43kD |
| Background | The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013], |
| Function | disease:Defects in P2RX1 are a cause of bleeding disorder [MIM:600845].,function:Ligand gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death.,online information:P2RX1 entry,online information:P2X receptor entry,similarity:Belongs to the P2X receptor family.,subunit:Homo- or heteropolymers., |
| Subcellular location | Membrane; Multi-pass membrane protein. |
| Expression | Blood,Lung,Placenta,Platelet,Urinary bladder,Urinary bladder smooth muscle, |
Additional Images
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Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES9967-50
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