Anti-Osteoprotegerin Rabbit pAb - 50 µL

Anti-Osteoprotegerin Rabbit pAb - 50 µL

Antibodies-Oncology
AO-03-GB113749-50
  • Specification: 50 µL
  • Applications: WB
  • Species: H,M,R
  • Dilution: 1: 300-1: 1000
  • Positive tissue: K562, Raji, heart, liver, kidney
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Product Information

Protein full name

Tumor necrosis factor receptor superfamily member 11B

Synonyms

Osteoclastogenesis inhibitory factor, Tnfrsf11b, Ocif, Opg, PDB5, TR1, TNFRSF11B, OCIF, OPG, PDB5

Uniprot ID

O08712

Immunogen

Recombinant protein corresponding to Mouse Osteoprotegerin

Isotype

IgG

Predicted MW./Observed MW.

46 kDa / 46-60 kDa

Purity

Affinity purification

Applications

ApplicationsSpeciesDilutionPositive Tissue
WBHuman, Mouse, Rat1: 500-1: 1000K562,Raji,kidney

Background

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Images

01SiSHKReLcYwim.jpg

 WB analysis of Osteoprotegerin(GB113749).
Sample: Protein treated by RIPA Lysis Buffer (G2002).
Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h.
Primary antibody: 1: 500, 4°C overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h.

02h32TYN8msEzJY.jpg

 WB analysis of Osteoprotegerin(GB113749).
Sample: Protein treated by RIPA Lysis Buffer (G2002).
Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h.
Primary antibody: 1: 500, 4°C overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h.

03WFUtf7eUI9qDs.jpg

 WB analysis of Osteoprotegerin(GB113749).
Sample: Protein treated by RIPA Lysis Buffer (G2002).
Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h.
Primary antibody: 1: 500, 4°C overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h.

Storage

Storage Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.15% ProClin300, 100 µg/mL BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

Datasheet: Download datasheet 1

Antibodies-Oncology
: AO-03-GB113749-50
: 10 Items
Hurry! only 10 items left in stock.

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