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Antibody Product Overview
| ELK.No | EM1050 |
| Product name | CD68 Mouse mAb |
| Reactivity | Human, Rat, Mouse |
| Applications | IHC |
| Other name | CD68 molecule, GP110, Macrosialin, SCARD1 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 968 |
| Human Swiss-Prot | P34810 |
| Source | Mouse |
| Isotype | IgG1 |
| Target | |
| Fields | |
| Gene name | |
| Protein name | |
| Human gene link | |
| Human Swiss link | |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthetic Peptide |
| Specificity | |
| Formulation | |
| Clonality | Monoclonal |
| Dilution | IHC 1:200 |
| Purification | |
| Concentration | 1mg/mL |
| Storage stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Molecular Weight (Da) | |
| Observed band (KD) | 37kDa |
| Background | The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells. |
| Function | |
| Subcellular location | Cell membrane and Endosome membrane. Lysosome membrane |
| Expression |
Additional Images
IHC staining of human tonsil tissue with CD68 mouse mAb(6F3) diluted at 1:200.
: EM1050-100
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