Anti-LC3B Rabbit pAb
|
Protein full name |
Microtubule-associated proteins 1A/1B light chain 3B |
|
Synonyms |
LC3, LC3B, MAP1A/1BLC3, MAP1A/MAP1B LC3 B, MAP1A/MAP1B light chain 3 B, MAP1ALC3, MAP1LC3B |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse LC3B |
|
Uniprot ID |
Q9GZQ8, Q62625, Q9CQV6 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Cytoplasm |
|
Predicted MW. / Observed MW. |
14/16 kDa / 14/16 kDa |
Applications
|
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
Hela, NIT/3T3 |
Background
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Images
|
|
Western blot analysis of LC3 (GB113801) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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