Product Information
|
Protein full name |
Dual specificity protein kinase TTK |
|
Synonyms |
Phosphotyrosine picked threonine-protein kinase, PYT, TTK, MPS1, MPS1L1, ESK, TTK protein kinase |
|
Uniprot ID |
P35761 |
|
Immunogen |
KLH conjugated Synthetic phosphopeptide corresponding to Mouse TTK |
|
Isotype |
IgG |
|
Predicted MW./Observed MW. |
96 kDa / 100 kDa |
|
Purity |
Affinity purification |
Applications
| Applications | Species | Dilution | Positive Tissue |
| WB | Mouse | 1: 300-1: 500 | testis |
Background
Mps1 family of kinases colocalizes with mitotic checkpoint proteins in kinetochores and/or spindle pole bodies/centrosomes. TTK has been shown to be a cell cycle-regulated kinase displaying maximum activity during M phase. Its kinase activity is required for proper chromosome segregation during mitosis through its involvements in microtubule-chromosome attachment error correction and the mitotic checkpoint.
Images
|
|
WB analysis of TTK/Mps1(GB115460). Sample: Protein treated by RIPA Lysis Buffer (G2002). Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1: 300, 4℃ overnight. Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h. |
Storage
| Storage | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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