Anti-IPL-1/STK13/Aurora C Rabbit pAb

Anti-IPL-1/STK13/Aurora C Rabbit pAb

Antibodies Oncology
AO-03-GB114842-50
STK-13,Aurora-C,Airk3,Aurora 3,AuroraC,STK 13,IPL1,Aurkc,Stk13,IPL 1,Aurora/IPL1-related kinase 3,GB114842,IPL-1/STK13/Aurora C,114842,Ark3,Aie1,ARK-3,Aik3,Aurora kinase C
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Product Information


Protein full name

Aurora kinase C

Synonyms

Aie1, Aik3, Airk3, Ark3, Stk13, Aurkc, ARK-3, Aurora 3, Aurora/IPL1-related kinase 3

Uniprot ID

O88445

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse IPL-1/STK13/Aurora C

Isotype

IgG

Purity

Affinity purification

Subcellular location

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Nucleus



Applications


Applications Species Dilution Positive Tissue
IHC/IF Mouse 1: 500-1: 1500 testis



Background

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.



Images

01bwaEw9HvvFMBD.jpg

 IHC analysis of IPL-1/STK13/Aurora C(GB114842).
Sample: Mouse testis, 4% PFA (G1101) 12-24h.
Antigen retrieval: Citrate buffer (pH 6.0) (G1201), 98℃, 20 min.
Primary antibody: 1: 500, 4℃ overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 200, RT, 1h.



Storage


Storage Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.


: AO-03-GB114842-50
: 10 Items
Hurry! only 10 items left in stock.

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