Anti-CDK5 Rabbit pAb

Anti-CDK5 Rabbit pAb

Antibodies Oncology
AO-03-GB115463-100
CDK-5,Cell division protein kinase 5,GB115463,PSSALRE,115463,GB115463100,CDK 5,CDK5,TPKII catalytic subunit,cyclin dependent kinase 5,Cyclin-dependent-like kinase 5
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Product Information


Protein full name

Cyclin-dependent-like kinase 5

Synonyms

CDK5, Cell division protein kinase 5, cyclin dependent kinase 5, PSSALRE, TPKII catalytic subunit

Uniprot ID

P49615

Immunogen

KLH conjugated Synthetic phosphopeptide corresponding to Mouse CDK5

Isotype

IgG

Predicted MW./Observed MW.

33 kDa / 33,30 kDa

Purity

Affinity purification



Applications


Applications Species Dilution Positive Tissue
WB Human 1: 300-1: 400 SHSY-5Y



Background

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins.Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18,SEPT5,SYN1,DNM1,AMPH,SYNJ1,CDK16, RAC1,RHOA,CDC42,TONEBP/NFAT5,MAPT/TAU,MAP1B, histone H1,p53/TP53,HDAC1,APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival,migration and differentiation, axonal and neurite growth,synaptogenesis,oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins.



Images

011vP5EVDBgR8o6.jpg

 WB analysis of CDK5(GB115463).
Sample: Protein treated by RIPA Lysis Buffer (G2002).
Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h.
Primary antibody: 1: 300, 4℃ overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h.



Storage


Storage Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.


: AO-03-GB115463-100
: 10 Items
Hurry! only 10 items left in stock.

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