Anti-CDKN2A/p19ARF Rabbit pAb

Anti-CDKN2A/p19ARF Rabbit pAb

Antibodies Oncology
AO-03-GB11703-100
p 19ARF,CDKN2,P16INK4A,P16-INK4A,P19ARF,Cyclin-dependent kinase inhibitor 2A,p-19ARF,Anti-CDKN2A/p19ARF Rabbit pAb,P19,Cyclin dependent kinase inhibitor 2A,GB11703,p-19,INK4A,CDK4I,MTS1,TP16,CDKN-2A,CDKN 2A,MTS-1,p 19,CMM2,11703,CDKN 2,MLM,Cdkn2a,CDKN-2,P16INK4,CDKN2A/p19ARF,P14ARF,ARF,INK4,GB11703100,CDKN2A,Cyclin-dependent kinase inhibitor 2A
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Product Information


Protein full name

Cyclin-dependent kinase inhibitor 2A

Synonyms

Cdkn2a, CDKN2A, ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1,  P19, P19ARF, Cyclin-dependent kinase inhibitor 2A, Cyclin dependent kinase inhibitor 2A

Uniprot ID

Q64364

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse p19ARF

Isotype

IgG

Predicted MW./Observed MW.

19 kDa / 20 kDa

Purity

Affinity purification



Applications


Applications Species Dilution Positive Tissue
WB Mouse, Rat 1: 500-1: 1000 liver, brain



Background

P19ARF Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression.



Images

01K41IbjKkwiJW6.jpg

 WB analysis of CDKN2A/p19ARF(GB11703).
Sample: Protein treated by RIPA Lysis Buffer (G2002).
Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h.
Primary antibody: 1: 500, 4℃ overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h.



Storage


Storage Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.


: AO-03-GB11703-100
: 10 Items
Hurry! only 10 items left in stock.

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