Product Information
|
Protein full name |
Endoglin |
|
Synonyms |
Cell surface MJ7/18 antigen, CD105, Eng, Edg, FLJ41744, HHT1, ORW, ORW1, END, ENG |
|
Uniprot ID |
Q63961 |
|
Immunogen |
Recombinant protein corresponding to Mouse CD105 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
conjugation |
FITC |
|
Subcellular location |
Cell membrane |
Applications
| Applications | Species | Dilution | Positive Tissue |
| FC | Mouse | 1: 100-1: 300 | bend.3 |
Background
Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis.
Images
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Flow cytometric analysis of CD105. Sample: bend.3. Antibody: FITC conjugated Anti-CD105 Rabbit mAb(ZB115656-FITC red histogram), 1: 100, RT 30 min. Control antibody: FITC conjugated Goat Anti-Rabbit lgG (GB22303, open histogram), 1: 200, RT 30 min. |
|
|
Flow cytometric analysis of CD105. Saple:m NIH3T3. Antibody: FITC conjugated Anti-CD105 Rabbit mAb(ZB115656-FITC red histogram), 1: 100, RT 30 min. Control antibody: FITC conjugated Goat Anti-Rabbit lgG (GB22303, open histogram), 1: 200, RT 30 min. |
Storage
| Storage | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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