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Product Information
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Protein full name |
Dickkopf-related protein 2 |
|
Synonyms |
Dickkopf-2, Dickkopf related protein 2, DKK-2, DKK2, hDkk 2, mDkk-2 |
|
Uniprot ID |
Q9QYZ8 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse DKK2 |
|
Isotype |
IgG |
|
Predicted MW./Observed MW. |
28 kDa / 28 kDa |
|
Purity |
Affinity purification |
Applications
| Applications | Species | Dilution | Positive Tissue |
| WB | Mouse | 1: 1000-1: 2000 | kidney, heart, lung |
Background
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Images
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WB analysis of DKK2(GB113829). Sample: Protein treated by RIPA Lysis Buffer (G2002). Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1: 2000, 4℃ overnight. Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h. |
Storage
| Storage | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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