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Product Information
|
Protein full name |
Spermatogenic leucine zipper protein 1 |
|
Synonyms |
BHLH-Zip transcription factor SPZ1, Spermatogenic Zip 1, Spz1, NYD TSP1, PP1C gamma 2, PPP1R148, Protein phosphatase 1, regulatory subunit 148 , Testis specific protein 1 |
|
Uniprot ID |
Q99MY0 |
|
Immunogen |
Recombinant protein corresponding to Mouse SPZ1 |
|
Isotype |
IgG |
|
Predicted MW./Observed MW. |
43 kDa / 43 kDa |
|
Purity |
Affinity purification |
Applications
| Applications | Species | Dilution | Positive Tissue |
| WB | Mouse, Rat | 1: 500-1: 1000 | brain, kidney, testis |
Background
Spermatogenic leucine zipper protein 1 is a member of the basic helix-loop-helix (bHLH) family of transcription factors which is expressed specifically in the testis and epididymis. Studies show that SPZ1 acts downstream of mitogen-activated protein kinase (MAPK), an extracellular signal-regulated kinase 1/2 to up-regulate cell proliferation and tumorigenesis. Also, through an interaction with proliferating cell nuclear antigen (PCNA) promoter, SPZ1 induced cell proliferation concomitant with an increase in PCNA gene expression.
Images
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|
WB analysis of SPZ1(GB111749). Sample: Protein treated by RIPA Lysis Buffer (G2002). Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1: 500, 4℃ overnight. Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h. |
Storage
| Storage | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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