Anti-Vimentin Mouse mAb

Anti-Vimentin Mouse mAb

Antibodies-Oncology
AO-03-GB14167-50
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Product Information


Protein full name

Vimentin

Gene Id

7431

Immunogen

Synthesized peptide derived from human Vimentin

Uniprot ID

P08670

Source

Mouse/IgG2b, Kappa

Concentration

1 mg/ml

Purity

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.



Applications


IHC/IF

Human

1: 200-1: 500

colon cancer, renal carcinoma



Background


Vimentin, also named as VIM, belongs to the intermediate filament family. Vimentin is class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is important for stabilizing the architecture of the cytoplasm. Monocyte-derived macrophages secrete vimentin into the extracellular space in vitro. Secretion of vimentin was enhanced by the proinflammatory cytokine tumor necrosis factor-alpha (TNFA; 191160) and inhibited by the antiinflammatory cytokine IL10 (124092), suggesting that vimentin is involved in the immune response. Vimentin has specialized functions that contribute to specific dynamic cellular processes. As a phosphoprotein, 55-60 kDa of vimentin proteins can be observed due to the different phosphorylation level. Isoforms of vimentin (49 kDa and 60 kDa) had also been reported.



Images


1665623383670637203.png

Immunohistochemistry analysis of paraffin embedded human colon cancer using vimentin (GB14167) at dilution of 1: 200

1665623383700330713.png

Immunohistochemistry analysis of paraffin embedded human renal carcinoma using vimentin (GB14167) at dilution of 1: 200


Storage


StorageStore at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage BufferLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.



NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.


Antibodies-Oncology
: AO-03-GB14167-50
: 10 Items
Hurry! only 10 items left in stock.

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