Anti-RASSF1 Rabbit pAb

Anti-RASSF1 Rabbit pAb

Antibodies Oncology
AO-03-GB114356-100
123F2,RASSF1,114356,RASSF-1,RASSF 1,REH3P21,NORE2A,RDA32,GB114356100,GB114356,Ras association domain-containing protein 1
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Product Information


Protein full name

Ras association domain-containing protein 1

Synonyms

123F2, NORE2A, RDA32, REH3P21

Uniprot ID

Q99MK9

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Rassf1

Isotype

IgG

Predicted MW./Observed MW.

39 kDa / 43 kDa

Purity

Affinity purification



Applications


Applications Species Dilution Positive Tissue
WB Mouse, Rat 1: 800-1: 1200 kidney, skin, liver



Background

Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform.



Images

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 WB analysis of RASSF1(GB114356).
Sample: Protein treated by RIPA Lysis Buffer (G2002).
Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h.
Primary antibody: 1: 1000, 4℃ overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h.



Storage


Storage Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.


: AO-03-GB114356-100
: 10 Items
Hurry! only 10 items left in stock.

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