Anti-IKB beta Rabbit pAb - 100 µL
   

Anti-IKB beta Rabbit pAb - 100 µL

Antibodies-Oncology
AO-03-GB11306-100
  • Specification: 100 µL
  • Applications: IHC | IF
  • Species: H,M,R | H,M,R
  • Dilution: 1:300-1:600 | 1:300-1:600
  • Positive tissue: lung, kidney, colon, liver, testis | lung, kidney, colon, liver, testis
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Product Information

Protein full name

NF-kappa-B inhibitor beta

Synonyms

I kappa B beta, IkappaBbeta, IkB B, IkB beta, IKBB, NF kappa B inhibitor beta, NF kappa BIB, NFKBIB, TR interacting protein 9, TRIP 9, TRIP9, IKBB, IkB-beta, NFKB inhibitor beta

Uniprot ID

Q60778

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse IKB-beta

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Nucleus

Applications

ApplicationsSpeciesDilutionPositive Tissue
IHC/IFHuman, Mouse, Rat1: 300-1: 600colon, lung cancer, lung

Background

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Images

01E02u4PI3POyHt.jpg

 IHC analysis of IKB beta(GB11306).
Sample: Human colon, 4% PFA (G1101) 12-24h.
Antigen retrieval: Citrate buffer (pH 6.0) (G1201), 98°C, 20 min.
Primary antibody: 1: 300, 4°C overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 200, RT, 1h.

02WG8KAnfAJp3UO.jpg

 IHC analysis of IKB beta(GB11306).
Sample: Mouse kidney, 4% PFA (G1101) 12-24h.
Antigen retrieval: Citrate buffer (pH 6.0) (G1201), 98°C, 20 min.
Primary antibody: 1: 300, 4°C overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 200, RT, 1h.

03j3ILH1j2K2iVz.jpg

 IHC analysis of IKB beta(GB11306).
Sample: Mouse lung, 4% PFA (G1101) 12-24h.
Antigen retrieval: Citrate buffer (pH 6.0) (G1201), 98°C, 20 min.
Primary antibody: 1: 300, 4°C overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 200, RT, 1h.

04J3FOAFfDDsaxz.jpg

 IHC analysis of IKB beta(GB11306).
Sample: Rat liver, 4% PFA (G1101) 12-24h.
Antigen retrieval: Citrate buffer (pH 6.0) (G1201), 98°C, 20 min.
Primary antibody: 1: 300, 4°C overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 200, RT, 1h.

05lOXA40l1atVBe.jpg

 IHC analysis of IKB beta(GB11306).
Sample: Rat testis, 4% PFA (G1101) 12-24h.
Antigen retrieval: Citrate buffer (pH 6.0) (G1201), 98°C, 20 min.
Primary antibody: 1: 300, 4°C overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 200, RT, 1h.

Storage

Storage Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.15% ProClin300, 100 µg/mL BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

Datasheet: Download datasheet 1

Antibodies-Oncology
: AO-03-GB11306-100
: 10 Items
Hurry! only 10 items left in stock.

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