Product Information
Protein full name | Mitogen-activated protein kinase kinase kinase 14 |
Synonyms | MAP3K14, FTDCR1B, HS, HSNIK, NIK, Mitogen-activated protein kinase, kinase, kinase 14, Map3k14 |
Uniprot ID | Q9WUL6 |
Immunogen | Recombinant protein corresponding to Mouse MAP3K14 |
Isotype | IgG |
Predicted MW./Observed MW. | 104 kDa / 104 kDa |
Purity | Affinity purification |
Applications
| Applications | Species | Dilution | Positive Tissue |
| WB | Human | 1: 500-1: 1000 | A549, HeLa, HepG2 |
Background
Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an enzyme encoded by the MAP3K14 gene. This protein is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-κB activity. It is a critical kinase of the alternative NF-κB activation pathway. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-κB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
Images
| WB analysis of NFkB Inducing Kinase NIK(GB11768). Sample: Protein treated by RIPA Lysis Buffer (G2002). Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1: 500, 4°C overnight. Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 µg/mL BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
Datasheet: Download datasheet 1
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