Anti-METTL1 Rabbit pAb

Anti-METTL1 Rabbit pAb

Antibodies Oncology
AO-03-GB113122-50
METTL1,TRM8,METTL 1,Methyltransferase-like protein 1,GB113122100,METTL-1,tRNA(m7G46) methyltransferase,GB113122,YDL201w,113122,methyltransferase like 1,C12orf1,tRNA (guanine-N(7)-)-methyltransferase,mettl14
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Product Information


Protein full name

tRNA (guanine-N(7)-)-methyltransferase

Synonyms

Methyltransferase-like protein 1, C12orf1, methyltransferase like 1, METTL1, TRM8, tRNA(m7G46) methyltransferase, YDL201w

Uniprot ID

Q9Z120

Immunogen

Recombinant protein corresponding to Mouse METTL1

Isotype

IgG

Predicted MW./Observed MW.

31 kDa / 31 kDa

Purity

Affinity purification



Applications


Applications Species Dilution Positive Tissue
WB Human 1: 300-1: 500 A549, U-251MG, A-431



Background

METTL1 methyltransferase mediates m7G methylation within miRNAs and regulates cell migration via its catalytic activity. METTL1 can be inactivated by phosphorylation at Ser27 by protein kinase B (PKBα). Overexpression of METTL1 is widely observed among human cancers. It is also crucial for the regulation of chemoresistance in cancer treatment. In addition, mutations in the human N7-methylguanosine (m7G) methyltransferase complex METTL1/WDR4 cause primordial dwarfism and brain malformation.



Images

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 WB analysis of METTL1(GB113122).
Sample: Protein treated by RIPA Lysis Buffer (G2002).
Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h.
Primary antibody: 1: 500, 4℃ overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h.



Storage


Storage Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.


: AO-03-GB113122-50
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