Anti-P35 Rabbit pAb

Anti-P35 Rabbit pAb

Antibodies Oncology
AO-03-GB111614-50
Tau protein kinase II 23 kDa subunit,CDK5P35,P 35,Cdk5r1,111614,P-35,P35,GB111614,Cyclin-dependent kinase 5 regulatory subunit 1,Neuronal CDK5 activator,CDK5 activator 1,TPKII regulatory subunit,Cyclin-dependent kinase 5 activator 1
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Product Information


Protein full name

Cyclin-dependent kinase 5 activator 1

Synonyms

CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, TPKII regulatory subunit, Tau protein kinase II 23 kDa subunit, Cdk5r1, CDK5P35, Neuronal CDK5 activator

Uniprot ID

P61809

Immunogen

Recombinant protein corresponding to Mouse P35

Isotype

IgG

Predicted MW./Observed MW.

34 kDa / 35 kDa

Purity

Affinity purification



Applications


Applications Species Dilution Positive Tissue
WB Mouse, Rat 1: 500-1: 1000 hippocampus, brain, spinal cord



Background

Cyclin dependent kinase-5 (Cdk5), is an atypical but essential member of the Cdk family of proline-directed serine/threonine kinases. CDK5R1 encodes p35, a specific activator of the serine/threonine kinase CDK5, which plays a central role in neuronal migration and differentiation during central nervous system development. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form.The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location.



Images

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 WB analysis of P35(GB111614).
Sample: Protein treated by RIPA Lysis Buffer (G2002).
Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h.
Primary antibody: 1: 500, 4℃ overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h.



Storage


Storage Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.


: AO-03-GB111614-50
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Hurry! only 10 items left in stock.

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