Anti-XIAP Rabbit pAb

Anti-XIAP Rabbit pAb

Antibodies Oncology
AO-03-GB111208-100
IAP-3,GB111208,API3,GB111208100,111208,hILP,XIAP,ILP,IAP3,hIAP3,X-linked IAP,BIRC4,Inhibitor of apoptosis protein 3,Baculoviral IAP repeat-containing protein 4,IAP-like protein,E3 ubiquitin-protein ligase XIAP
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Product Information


Protein full name

E3 ubiquitin-protein ligase XIAP

Synonyms

Baculoviral IAP repeat-containing protein 4, IAP-like protein, API3, BIRC4, IAP3, XIAP, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP3, X-linked IAP, Xiap, IAP-3, ILP1, MIHA, XLP2, X-linked inhibitor of apoptosis

Uniprot ID

Q60989

Immunogen

Recombinant protein corresponding to Mouse XIAP

Isotype

IgG

Predicted MW./Observed MW.

57 kDa / 57 kDa

Purity

Affinity purification



Applications


Applications Species Dilution Positive Tissue
WB Human, Mouse 1: 500-1: 1000 MCF7, HT-29, Jurkat



Background

XIAP, also named as API3, BIRC4 and IAP3, belongs to the IAP family. It has E3 ubiquitin-protein ligase activity. It mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. XIAP is an inhibitor of caspase-3, -7 and -9. It mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B. XIAP is an apoptotic suppressor. It is ubiquitinated and degraded by the proteasome in apoptotic cells.



Images

01hiNRilXXQgncU.jpg

 WB analysis of XIAP(GB111208).
Sample: Protein treated by RIPA Lysis Buffer (G2002).
Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h.
Primary antibody: 1: 500, 4℃ overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h.



Storage


Storage Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.


: AO-03-GB111208-100
: 10 Produits
Hurry! only 10 items left in stock.

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