Anti-Caspase-3 Rabbit pAb
   

Anti-Caspase-3 Rabbit pAb

Antibodies Oncology
AO-03-GB11009-1-100
Caspase 3,Caspase3,GB11009-1,CPP32,CASP3,CPP32B,asp3,GB11009 1,11009-1,GB110091,SCA-1,GB110091100,Caspase-3,casepase,Caspase-3,Cleaved-caspase3,capase,Casepase3,capase3
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Product Information

Protein full name

Caspase-3

Synonyms

Casp3, CASP3, CPP32, CPP32B, SCA-1, Caspase 3

Immunogen

Recombinant protein corresponding to Mouse Caspase-3

Uniprot ID

P70677

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm

Applications

Species

Dilution

Positive Tissue

IHC/IF

Human, Rat, Monkey, Pig

1: 100-1: 200

breast cancer, liver cancer, colon cancer

Storage

Storage

Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Storage Buffer

PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol.

background

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.

Images

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IHC analysis of Caspase-3(GB11009-1).
Sample: Human breast cancer, 4% PFA (G1101) 12-24h.
Antigen retrieval: Citrate buffer (pH 6.0) (G1201), 98℃, 20 min.
Primary antibody: 1: 100, 4℃ overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 200, RT, 1h.

IHC analysis of Caspase-3(GB11009-1).
Sample: Human liver cancer, 4% PFA (G1101) 12-24h.
Antigen retrieval: Citrate buffer (pH 6.0) (G1201), 98℃, 20 min.
Primary antibody: 1: 100, 4℃ overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 200, RT, 1h.

IHC analysis of Caspase-3(GB11009-1).
Sample: Human colon cancer, 4% PFA (G1101) 12-24h.
Antigen retrieval: Citrate buffer (pH 6.0) (G1201), 98℃, 20 min.
Primary antibody: 1: 100, 4℃ overnight.
Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 200, RT, 1h.

For Research Use Only!                                               Ver. No.: V2.1-20260413


: AO-03-GB11009-1-100
: 10 Produits
Hurry! only 10 items left in stock.

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