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Cleaved-Cathepsin A 32k (R326) rabbit pAb
AO-06-ES1024-100
Antibody Product Overview
| ELK.No | ES1024 |
| Product name | Cleaved-Cathepsin A 32k (R326) rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | CTSA; PPGB; Lysosomal protective protein; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A; Protective protein cathepsin A; PPCA; Protective protein for beta-galactosidase |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 5476 |
| Human Swiss-Prot | P10619 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Cathepsin A |
| Fields | >>Lysosome;>>Renin-angiotensin system |
| Gene name | CTSA |
| Protein name | Lysosomal protective protein |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 19025 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P16675 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PPGB. AA range:277-326 |
| Specificity | Cleaved-Cathepsin A 32k (R326) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin A 32k protein resulting from cleavage adjacent to R326. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 33kD |
| Background | This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015], |
| Function | catalytic activity:Release of a C-terminal amino acid with broad specificity.,disease:Defects in CTSA are the cause of galactosialidosis [MIM:256540]. It is an autosomal recessive disease.,function:Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.,similarity:Belongs to the peptidase S10 family.,subunit:Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked., |
| Subcellular location | Lysosome. |
| Expression | Brain,Liver,Placenta,Platelet,Skin,Uterus, |
Additional Images
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Western Blot analysis of various cells using Cleaved-Cathepsin A 32k (R326) Polyclonal Antibody
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Western blot analysis of lysates from 293 and Jurkat cells, treated with etoposide 25uM 1h, using PPGB (32k,Cleaved-Arg326) Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES1024-100
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